The effects of calcium fluoride (CaF2) doping on the optical and physical and chemical properties of Ytterbium fluoride (YbF3) materials were studied. Pure YbF3 thin films and YbF3 thin films doped with different proportions of CaF2 were deposited by electron beam and thermal evaporation, respectively. The characteristics of single layer were measured by spectrometer, stress measurement system, X-ray Diffraction (XRD), Atomic Force Microscope (AFM) and other measuring devices. The optical constants were fitted by the classical Lorentz oscillator model. The results show that the single-layer film with better optical and physical and chemical properties is obtained by electron beam deposition, in the condition of 1% CaF2 doping. A long-wave infrared anti-reflection multi-layer sample was designed and fabricated and its spectrum and reliability test were carried out. The results show that its transmittance in the long-wave infrared region is as high as 99%, and the reliability meets the requirements of space application.