This study used a terahertz metamaterial sensor for the rapid and accurate detection of the antithrombotic drug Plavix, addressing the increasing demand for efficiency and sensitivity in drug content monitoring. Utilizing the terahertz vibration characteristics of Plavix, characteristic absorption peaks within the 1~3 THz band were identified. Based on these findings, a dual-polarization resonance metamaterial sensor was designed to simultaneously enhance the sensing signals of these characteristic absorption peaks. Experimental results indicate that the sensor attains a high level of fit (R2>0.97) for quantitative analysis in the quantitative detection of Plavix through the established two-indicator decision model. Consequently, the terahertz metamaterial sensing technology presented in this study exhibits superior performance in monitoring Plavix content and offers a new tool for clinical drug monitoring and broader biochemical sample analysis.