The relationship of IRFPA between response characteristic and incidence radiation,integral time was analyzed by using the practical response data.The essence of two point blackbody radiometric calibration non-uniformity correction algorithm was proposed by using different response data of high and low temperature to calculate gain coefficient and bias coefficient.Resembling to this,different response data could also be gathered by adjusting integral time.Therefore,non-uniformity correction(NUC) algorithm based on integral time regulation was studied,one and two point calibration correction algorithm was first proposed,then combined with multi-resolution wavelet decomposition,a new adaptive NUC algorithm was presented.Experiments show that the proposed scheme achieves good performance when applied in real imaging system.