In combination with the engineering applications of image guided weapons, a subpixel correlation tracking method with MEMS-IMU information fusion is proposed. In this method, an error compensation method based on rate measurement is used to compensate the measurement error of MEMS-IMU, so as to achieve the fusion of MEMS-IMU data and image heterogeneous data. Meanwhile, a subpixel correlation tracking algorithm based on template interpolation is employed to improve tracking precision. The result shows that this method not only can well solve the conflict problem between the real-time capacity and the complexity of the algorithm used when the image tracking precision is improved solely by image information, but also can improve the image tracking precision under moving bases effectively.