Infrared smoke simulation is a key technique in the application field of infrared imaging guidance weapons. Under a typical environmental condition, the infrared imaging tracking of the smoke of a moving target is carried out. According to the infrared images and related data obtained in the field test of a given smoke pot, a method for modifying the classic infrared smoke model is proposed. In a scene simulation program, the elements such as background and target are utilized. By comparing them to the measured data, an image database is formed. The dynamic scene simulation of infrared smoke interference is implemented by using a real time layered transparent image drawing method. The simulation uses a scene window of 360?240 and a frame rate of 40 frames per second. It can meet the real time simulation requirement of the conventional imaging infrared guidance process.