Firstly, the synthesizable hardware description language (HDL) codes are generated in the design based on a simulink module by using the HDL Coder. Then, the FPGA is used to implement the dead pixel replacement in the image data stream of an infrared detector. By taking the dead pixel replacement of an uncooled infrared imaging system for example, the development process is described. Because the concerns are transferred to the upper design levels such as system architects and simulation, the development efficiency is improved and good image processing effectiveness is obtained.