To improve the technology of infrared imaging simulation and accelerate the development of infrared guided weapons, the target scene radiation model, atmospheric transmission model and infrared detector model are analyzed respectively. Taking the F16 aircraft as an example, a dynamic infrared image simulation process based on Creator and Vega is described in detail. On the basis of MFC and Vega API, a friendly interface which can switch between different simulation conditions and adjust parameters is developed. The interface is successfully used to achieve the dynamical control of infrared images and provides great convenience and good effectiveness for simulation.