In order to observe the infrared body surface temperature changes of related meridian acupoints in insomnia patients, the body surface temperature of the acupoints on Du meridian, bladder, spleen, heart channel and yinqiao, yangqiao meridian of insomnia patients and healthy volunteers was collected by an infrared human skin temperature rapid screening instrument. The temperature difference in the same name acupoints of the two groups(underarm temperature-acupoint temperature) was compared. The results showed that the temperature of the back and neck points on Du meridian and bladder in the insomnia group decreased more significantly than the control group (P <0.05). Although the temperature of the spleen meridian points decreased, there was no significant difference compared with the control group. In the heart meridian of the acupoints, the temperature decreased in some cases and increased in some cases, which was significantly different from the control group (P <0.05). The temperature of leg points on yinqiao meridian decreased (P＜0.05), and the temperature of head points on yangqiao meridian increased (P＜0.05). It can be seen that the changes of body temperature in the meridians of the insomnia patients reflect the intrinsic pathogenesis of insomnia: “the Yang Hyperactivity is on the upper side, the yin is lower than the lower, the yang is not in the yin”. The clinical treatment can be selected according to the results of infrared thermography.