The purpose of this study is to explore the characteristics of infrared heat maps in patients with insanity and to lay the foundation for the application of infrared thermography detection technology in the diagnosis of insanity. Using a simple random sampling survey and a comparison method, a total of 600 people′s infrared heat map data was collected. The ratio of the number in the crazy group to the number in the normal group was 5∶1. Syndrome classification was performed on patients with insanity. Infrared thermal imaging data collection was performed for all subjects. The relative temperature differences (ie ΔT) of 15 areas including upper coke, middle coke, lower coke, governor meridian, ren meridian were detected, and paired-samples T tests were performed. The results showed that 91.6% of the patients with insanity had deficiency syndromes. Compared with the normal group, the ΔT in the four measurement areas of upper coke, governor meridian, virtual and right flank was significantly different (P <0.05). Among them, the ΔT of upper coke, governor meridian and virtual for the epileptic patients was lower than that of the normal people, while the ΔT of the right flank was higher than the normal people. The majority of patients with clinical epilepsy have deficiency syndromes. As an objective evaluation index of non-invasive functional images, infrared thermal imaging has clinical application value in the diagnosis of insanity.