To meet the calibration demands of infrared measurement and control developed rapidly in China in recent years, a measurement and control system for a large blackbody radiation source used for calibrating infrared detection systems with larger field-of-view angle and higher resolution is designed. The blackout radiation surface of the large blackbody radiation source is made of 7075 cold-treated forging alloy. Its effective radiation area reaches 1200 mm×1200 mm. For such a large blackbody radiation source, there are no any ready-made control methods and means which can verify whether its technical specifications meet the design requirements. According to the main technical specifications of the large blackbody, the measurement and control method is given. The accuracy of the blackbody measurement and control system is verified by the data obtained in actual measurement and control.