Study of in-vivo breast cancer in a subcutaneous xenograft mouse model using terahertz imaging
投稿时间:2019-09-26  修订日期:2020-06-04  download
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武丽敏 天津大学精密仪器与光电子工程学院激光与光电子研究所 
廖斌 陆军军医大学第一附属医院神经外科 
徐德刚 天津大学精密仪器与光电子工程学院激光与光电子研究所 
王与烨 天津大学精密仪器与光电子工程学院激光与光电子研究所 
葛梅兰 天津大学精密仪器与光电子工程学院激光与光电子研究所 
张超楠 天津大学生命科学学院天津市微纳生物材料与检疗工程技术中心 
李佳桦 天津大学生命科学学院天津市微纳生物材料与检疗工程技术中心 
孙忠成 天津大学精密仪器与光电子工程学院激光与光电子研究所 
陈图南 陆军军医大学第一附属医院神经外科 
冯华 陆军军医大学第一附属医院神经外科 
姚建铨 天津大学精密仪器与光电子工程学院激光与光电子研究所 
Abstract:Breast cancer (BC) is one of the most common diseases in women. The accurate detection for BC is very important in clinical practice. In this paper, in-vivo breast cancer in a subcutaneous xenograft mouse was studied with the continuous-wave terahertz (THz) reflection imaging system at 2.52THz. The high reflection region in THz images of in-vivo subcutaneous xenograft mouse corresponded well to the tumor area in visible. The difference value of 15% between tumor and normal tissues was observed. For the gold standard, the tumor areas at different depths from the surface of skin in mouse model were obtained by hematoxylin and eosin-stained images. The tumor areas increased with the increase of depth. In contrast with THz image, it is found that the tumor area in THz image was similar to that in hematoxylin and eosin-stained images at a depth of 460μm. Therefore, the detection depth of THz wave in in-vivo breast cancer in a subcutaneous xenograft tissue was about 460μm under this imaging system.
keywords:Breast cancer  continuous terahertz wave  reflection imaging  
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Copyright:《Journal of Infrared And Millimeter Waves》