Environmental influence to signal output of infrared focal plane array (IRFPA) was analyzed. A nonuniformity correction (NUC) algorithm based on environmental and target temperature was proposed. Firstly, signal was captured by UL01011 staring infrared detector, an exponential response model was established according to the principle of least square. Secondly, nonuniformity was corrected by this model. Experimental results show the proposed algorithm can give an exactly response in wider environmental temperature and improve NUC precision effectively.