A new adaptive multi-point nonuniformity correction algorithm for IRFPA was presented. The algorithm acquires the weights of detector working under a demarcated radiation by using adaptive filtering. The temperature floating of nonuniform IR images was removed by making use of the acquired weights. In the end, the muiti-point nonuniformity correction based on three order spline interpolation to the removed temperature floating IR images is made. The algorithm is with high correction precision, broad dynamic range and easy to realize in engineering.