用于相干拉曼散射成像的光纤光源研究进展
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1.复旦大学 工程与应用技术研究院 应用表面物理国家重点实验室 物理学系 义乌研究院 人类表型组研究院 微纳光子结构教育部重点实验室,上海 200433;2.上海理工大学 能源与动力工程学院,上海 200093;3.上海理工大学 光电信息与计算机工程学院,上海 200093

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O43

基金项目:

国家自然科学基金(62425501)


Research progress on fiber-based laser sources for coherent Raman scattering imaging
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Affiliation:

1.Academy for Engineering and Technology, State Key Laboratory of Surface Physics and Department of Physics, Yiwu Research Institute, Human Phenome Institute, Key Laboratory of Micro and Nano Photonic Structures(Ministry of Education), Fudan University, Shanghai 200433, China;2.The School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;3.The School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

Fund Project:

Supported by the National Natural Science Foundation of China(62425501)

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    摘要:

    相干拉曼散射显微镜凭借其化学特异性、无标记成像能力、高光谱分辨率和高灵敏度,被广泛认为是解决生物医学问题的强大工具。然而,相干拉曼散射成像技术的临床应用长期以来受到环境敏感性的影响和大体积固体激光器的阻碍。超快光纤激光器凭借其紧凑性和稳定性,能够有效克服这些缺点。文章对于光纤光源在相干拉曼散射成像中的不同实现方法和研究进展进行了评述,主要包括超连续谱光纤光源、孤子自频移光纤光源、光纤参量振荡器、同步光纤光源,并对未来发展进行了展望。

    Abstract:

    Coherent Raman scattering microscopy is widely regarded as a powerful tool for solving biomedical problems due to its chemical specificity, label-free imaging capability, high spectral resolution and high sensitivity. However, the clinical application of coherent Raman scattering imaging technology has long been hindered by environmental sensitivity and large volume solid-state lasers. Ultrafast fiber lasers, with their compactness and stability, can effectively overcome these shortcomings. In this paper, different realization methods and research progress of fiber-based laser sources in coherent Raman scattering imaging are reviewed, including supercontinuum fiber source, soliton self-frequency shift fiber source, fiber optical parametric oscillator and synchronized fiber source, and the future development is prospected.

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李佳颖,胡东升,庄浩,李依泽,季敏标.用于相干拉曼散射成像的光纤光源研究进展[J].红外与毫米波学报,2025,44(5):639~651]. LI Jia-Ying, HU Dong-Sheng, ZHUANG Hao, LI Yi-Ze, JI Min-Biao. Research progress on fiber-based laser sources for coherent Raman scattering imaging[J]. J. Infrared Millim. Waves,2025,44(5):639~651.]

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  • 收稿日期:2025-03-19
  • 最后修改日期:2025-07-24
  • 录用日期:2025-04-16
  • 在线发布日期: 2025-07-17
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