The property of spatial frequency of the nonuniformity noise in IRFPA was studied. And the conclusion is that low frequency noise generally dominates the inherent IRFPA nonuniformity noise. The experiment with real IRFPA data demonstrates the same conclusion. To avoid the disadvantage of the traditional spatial adaptive nonuniformity correction denoising the low frequency dominated nonuniformity noise, a feasible approach for nonuniformity correction of IRFPA, which integrates one-point correction with spatial adaptive correction scheme, was proposed in this study. Experiments show that the proposed scheme can achieve good performance when low frequency noise is dominant.