Striping is new problem for imaging spectroradiometer data, which is obtained by multi sensor scanning on spacecraft. The reason causing stripes and the development of striping removal methods were described, and the principle of matching empirical distribution functions was introduced in detail. By using this method, some experiments were done to destripe imaging spectroradiometer data of SZ 3. The result shows that the method of matching empirical distribution functions is available for destirping imaging spectroradiometer data of SZ 3, and the quality of image is improved obviously. This will help to process the future similar instruments data.