By studying two interband cascade laser (ICL) wafers with structural parameters that deviated considerably from the design, the durability of the device performance against structural variations was explored. Even with the lasing wavelength blue shifted by more than 700 nm from the designed value near 4.6 μm at 300 K, the ICLs still performed very well with a threshold current density as low as 320 A/cm² at 300 K, providing solid experimental evidence of the tolerance of ICL performance on structural variations.