In the traditional design of electro-optical imaging systems, the optical and electronic subsystems are designed separately. This leads to a reduction in the level of coordination between the parameterization of the both subsystems, resulting in imperfect subsystem compatibility. In order to improve the compatibility between subsystems, shorten a design time and reduce the developments, we propose a co-design method. Based on the end-to-end optoelectronic performance evaluation, the multi-objective and multi-parameter optimization algorithm is used to optimize the configuration parameters of the optoelectronic subsystem. A space infrared imaging system was optimized by this method and imaged good pictures in orbit. The results show that the method has a positive role in optimizing the configuration parameters of the electro-optical imaging system and evaluating the performance of the electro-optical imaging system.