The components and operation principle of an infrared imaging guided system are presented. The mechanism of an infrared imaging guided missile in smoke jamming is analyzed. A method for comprehensively evaluating the combat efficiency of infrared imaging guided missiles in smoke jamming is given. The method is based on digital simulation. It can obtain the kill probability of a missile in smoke jamming by combining the field test with the fuzzy analytic hierarchy process. It is of significance to the evaluation of the combat efficiency of infrared imaging guided missile systems.