Infrared radiation characteristics are an important part of studying the stealth technology of guided aircraft. Taking the AGM-88 high-speed anti-radiation guided aircraft as an example, a simulation and analysis study on the entire infrared radiation characteristics of the guided aircraft is carried out. The Reynolds-averaged turbulence model is used to carry out flow field simulation calculations, and the discrete transfer method is used to more accurately simulate the infrared radiation characteristics of the supersonic flow field. Then, the infrared radiation characteristics under different working conditions are compared. The results show that the Mach number of the incoming flow has an important influence on the temperature and infrared radiation intensity of the missile body. With the increase of the incoming flow Mach number, the infrared radiation intensity increases significantly, reaching a maximum of more than 400 W/Sr. The component with the largest infrared radiation brightness is the high-temperature, low-pressure, and low-speed reflow zone formed in the engine area, and the infrared radiation brightness can reach a maximum of more than 180 W/m². The pressure and temperature of the missile body head, wing and rudder area are relatively high, and the infrared radiation brightness is relatively large. This study can provide strong support for target detection and structural stealth optimization design of guided aircraft.