The two-point nonuniformity correction method is analyzed and the formula in the fix-point form is sequently deduced. Moreover, the algorithm is implemened on the hardware structure of DSP+FPGA. The DSP is used to change the data of float-point into fix-point, while the FPGA is used to fulfil the task of nonuniformity correction according to the fix-point fomula. Since the Pipelined technique is applied in the FPGA design, the processing speed can reach 80MHz for each pixel. The module has been designed on the APEXII series FPGA and performed well in the moving target infrared image proccessor project.