A high speed, high resolution, small-size and low-power-consumption imaging system based on a LUPA1300-2 CMOS image sensor is designed. By taking a FPGA as a sequential control program development platform, several modular programs including sensor driving, data processing, communication and data transfer etc are designed by a Verilog hardware description language. The function and structure of each module are analyzed and explained. The hardware circuit is developed on the basis of the imaging system frame proposed. Then, an imaging experiment is carried out on the whole imaging system. The experimental result shows that its driving timing is proper, its communication with the computer is effective, its data transfer is correct, its image quality is high and it can operate stably and reliably.