The driving algorithm for generating infrared scenes in an infrared imaging hardware-in-the-loop simulation system in real time is studied. According to the engineering application of real-time infrared scene generation in the infrared imaging hardware-in-the-loop simulation system, the initial war situation scene mapping algorithm for infrared scenes, the real-time mapping algorithm for dynamic war situation scenes and the selection algorithm for scene aiming points in real-time simulation are designed. Several problems of the application of real-time infrared scene generation in the infrared imaging hardware-in-the-loop simulation system are solved. These algorithms are verified in multi-mode static and dynamic simulation and tests.