In this paper, the influence of the response nonuniformity of infrared focal plane array (IRFPL) detectors on the sensitivity of imaging systems and the influence of the nonlinear response of the integration time of a single detection element on imaging quality are analyzed. An algorithm for correcting the response nonuniformity of infrared focal plane array detectors is proposed. The algorithm is based on the combination of scene movement scanning mean value adjustment with integration time adjusment. It can not only allow the system to obtain the response with good uniformity, but also allow the response to avoid the influence caused by the changing of integration time. So, it has further widened the practical application area of the infrared focal plane array detectors.